Expo sets a new standard in PAT implementation
PAT implementation gurus’ Expo Technologies talks to European Pharmaceutical Review about PAT and why they are at the top of their game.
View ArticleWyeth’s PAT variations submitted through the EMEA Worksharing Procedure
In June 2006, the EMEA called for nominations from companies to participate in the pilot phase of a worksharing exercise for Quality variations1. Worksharing is a key element in the revisions to the...
View ArticleLyophilization: cycle robustness and process tolerances, transfer and scale up
During the past 10-15 years, close attention has been paid to the development of optimal lyophilization cycles for different types of pharmaceuticals1-4. Recent advances in process control, such as the...
View ArticleSiemens: innovation, industry and implementation
Siemens seeks to deliver breakthrough innovations to give customers a unique competitive edge, in turn enabling societies to master their most vital challenges and creating sustainable value. Siemens...
View ArticlePeracetic acid in the study of rhIL-11 methionine oxidation
Recombinant human interleukin-eleven (rhIL-11) is a pleiotropic cytokine which stimulates stem cell proliferation and affects multiple cell types1. The protein has been demonstrated to provide clinical...
View ArticlePlatform technology for routine three dimensional cell culture
Cell culture assays play an important role during the first stages of pharmaceutical development. The design of such in vitro models is significant and data resulting from such tests directly...
View ArticleIn vitro toxicity screening as pre-selection tool
Drug discovery relies on massive screening of compound libraries with in vitro cell-based target assays. These pharmacological screens have been well accepted. For in vitro toxicological screening,...
View ArticleUtilisation of secondary screening
European Pharmaceutical Review has brought together four individuals from different sides of the scientific palette to discuss current and future issues surrounding secondary screening and maximising...
View ArticleHigh content imaging subpopulation analysis for phenotypic drug discovery
Phenotypic drug discovery (PDD) has come of age – again. Using a microscope to observe a cell, one of the oldest techniques available to a cellular biologist dates back to the 17th century studies of...
View ArticleMALDI FT-ICR MS platform for proteomics: Rationale for an offline approach...
MALDI FT-ICR MS platform for proteomics: Rationale for an offline approach and optimised implementation A number of sophisticated approaches have been developed to study the structure and function of...
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